Catherine Wistar Bache (1805-1886) was the point of connection between two of Philadelphia's most illustrious families of the late eighteenth century. Daughter of the physician Caspar Wistar, in November 1797 she married Dr. William Bache, who was the son of Richard Bache and the grandson of Benjamin Franklin. Primarily letters to Mrs. Bache (wife of Dr. William Bache) of Philadelphia, from Mrs. David Hosack (nee Mary Eddy), Mrs. Elizabeth Trist, and Mary Jones. The letters are personal and concern family life, activities of husbands, etc., with many references to Caspar Wistar, There are comments on diseases, education (at William and Mary College), war, and politics. References are also made to the deaths of Richard Bache and Caspar Wistar, and to Benjamin Franklin's Stockado (a musical instrument).

The family correspondence of Richard and Sarah Franklin Bache on a variety of topics including references to Benjamin Franklin and his estate. There is also a family genealogy.